In signal pathway activation, Fusobacterium nucleatum activates the NF-κB signaling pathway in CRC cells, leading to reduced miR-1322 expression, CCL20 activation, macrophage infiltration, and M2 macrophage polarization, which promote tumor immune evasion and the inflammatory response in the tumor microenvironment [45]. This evidence concerns the gene NFKB1 and colorectal carcinoma.