Lactic acid bacteria achieve this through the following mechanisms: enhancing CD8 T cell recruitment by interacting with immune cells via specific signaling mechanisms, activating related signaling pathways, and guiding CD8 T cells to migrate and accumulate in the tumor microenvironment, thereby strengthening the body’s anti-tumor immune response and inhibiting the proliferation and growth of colon tumor cells [49]. This evidence concerns the gene CD8A and colonic neoplasm.