PROS1 and focal segmental glomerulosclerosis: Building on this seminal work, CD2AP is now recognized as an adaptor/scaffolding protein that performs a wide range of functions including receptor endocytosis and trafficking to cell–cell interactions, signal transduction, cell adhesion and motility, etc. Importantly, mutations in the human gene are associated with a rare type of kidney injury known as focal segmental glomerulosclerosis (FSGS) [4–6].