Interestingly, loss of CD2AP in brain endothelial cells does not impact amyloidosis in the parenchyma nor does it trigger the accumulation of Aβ around vessels (a diseased condition called cerebral amyloid angiopathy that is observed in more than 90% of AD cases) in the PS2 APP mouse model of amyloidosis [36]. Here, CD2AP is linked to Alzheimer disease.