PRL and metabolic dysfunction-associated steatotic liver disease: Moreover, the circadian rhythmicity of genes involved in circadian rhythm, PRL signaling pathway, and lipid metabolism processes (including fatty acid biosynthesis, AMPK signaling pathway, peroxisome-proliferator-activated receptors signaling pathway) was significantly attenuated (Rhythmicity test P > 0.05), while genes associated with NAFLD gained oscillation and were significantly enriched (P = 0.01; Fig. 5a, Additional file 1: Fig. S7).