MARCHF5 and diabetic cardiomyopathy: Lu et al. demonstrated that irisin supplementation markedly elevated the expression of the mitochondrial ubiquitin ligase MITOL and maintained mitochondrial function in a model of diabetic cardiomyopathy, which was accompanied by decreased activation of the cGAS-STING pathway and GSDMD-dependent pyroptosis (Lu et al. 2024a).