This event subsequently activated the cGAS-STING-IRF3 pathway, contributing to detrimental cardiac remodeling and heart failure, whereas the knockdown of cGAS or STING alleviated these adverse effects by blunting sterile inflammation and promoting macrophage polarization towards the anti-inflammatory M2 subtype (Guo et al. 2023). This evidence concerns the gene STING1 and heart failure.