Han et al. demonstrated that mitochondrial oxidative stress in cardiomyocytes, arising from CKD, stimulates the cGAS-STING-NF-κB-ornithine decarboxylase (ODC1) axis, while the use of the STING inhibitor C-176 significantly mitigates cardiac hypertrophy (Han et al. 2022). Here, CGAS is linked to cardiac hypertrophy.