Extensive studies have revealed that the activation of cGAS-STING pathway is implicated in the pathophysiology of CVDs, including atherosclerosis, myocardial infarction (MI), ischemia-reperfusion (I/R) injury, myocarditis, cardiomyopathy, HF, and aortic aneurysm and dissection (AAD) (Liu et al. 2023b; Luo et al. 2020; Ma et al. 2023; Pham et al. 2021; Qin et al., 2023; Wang et al. 2024a; Zhai et al. 2024). This evidence concerns the gene CGAS and hydrops fetalis.