Investigations on myocardial tissues of mice challenged with angiotensin II (Ang II) or transverse aortic constriction (TAC) revealed that the inflammatory response mediated by the cGAS-STING-NF-κB axis in cardiomyocytes plays a pivotal role in the progression of HF associated with cardiac hypertrophy. The gene discussed is NFKB1; the disease is cardiac hypertrophy.