TNF and Sepsis: Sepsis is characterized by hyperinflammatory response, marked by the excessive release of cytokines such as interleukin (IL)−1β, IL-6, and tumor necrosis factor-α (TNF-α), as well as multiple organ dysfunction syndrome (MODS), which affects the heart, liver, kidneys, lungs, spleen, and brain (Lelubre and Vincent 2018).