In conclusion, our data suggest that R7-stimulated release of IL-6 is further enhanced by IL-17 or IFN-γ, cytokines that contribute to the pathogenesis of psoriasis, and that the release of IL-24 is upregulated by IL-4 or IL-13, cytokines that drive the pathogenesis of AD, or a combination of IL-17 and R7. This evidence concerns the gene IL4 and Alzheimer disease.