R7 binds to the extracellular domain of the receptor tyrosine kinase c-ros oncogene 1 (ROS1) and triggers ROS1 signaling as well as phosphorylation of several targets including STAT2 and STAT6 and changes in gene expression in hepatocellular carcinoma cells indicating that ROS1 can function as receptor for R760. This evidence concerns the gene ROS1 and hepatocellular carcinoma.