IL-17 and IFN-γ, which play a critical role in the pathogenesis of psoriasis, significantly enhanced the R7-triggered IL-6 secretion, and the Th2 cytokines IL-4 and IL-13, which play a critical role in the pathogenesis of AD, tended to enhance the stimulatory effect of R7 on IL-6 secretion. This evidence concerns the gene IL4 and Alzheimer disease.