ITGAM and pulmonary emphysema: Although CD11b+Ly6G-Siglec-F+ eosinophil levels remained unaffected even when Ly6G+ cells were completely depleted (Fig. S7A), emphysema symptoms were significantly alleviated (Fig. 8A), highlighting the crucial role of Siglec-F+ neutrophils in the exacerbation of emphysema.