Six essential transcription factors (TFs) (NFIL3, STAT3, NFKB1, USF1, USF2, and EGR1), 11 important drug chemicals (Cisplatin, Cyclosporine, perfluorooctanoic acid, Quercetin, Tretinoin, bisphenol A, Curcumin, Valproic Acid, Particulate Matter, Simvastatin, and Cadmium), seven related diseases (Atherosclerosis, Glioblastoma, Pulmonary Fibrosis, Asthma, Hepatitis B, Hepatitis C, and Diabetes Mellitus), and ten important RNA-binding proteins (RBPs) (CHTOP, EIF4E, HNRNPK, IGF2BP3, YTHDF3, HNRNPA2B1, RBM47, YBX1, RBFOX2, and RBM10). Here, EGR1 is linked to hepatitis B virus infection.