According to Genecard analysis, the top 4 genes with higher expression in pediatric DLBCL (FDR < 0.01 and log2 FC > 2, Fig. 1a) are involved in the differentiation of lymphocytes (NT5E), regulation of dendritic cell-induced T cell proliferation (CD209), T and B cell development and regulation of inflammation (TET1), and MHC class I and innate immune system-mediated antigen processing and presentation, in addition to their role in early hematopoiesis (CD34). The gene discussed is TET1; the disease is diffuse large B-cell lymphoma.