In addition, the overexpression in genes such as IKBKB, ALK, MYC, CD69, CD19, NRP1, NOS3 and PDGRFA, associated with the activation of oncogenic signaling pathways, cell proliferation, angiogenesis and tumor progression, may suggest that pediatric DLBCL could be more aggressive than adult cases, even though survival is better in children17. This evidence concerns the gene NOS3 and neoplasm.