In addition, the overexpression in genes such as IKBKB, ALK, MYC, CD69, CD19, NRP1, NOS3 and PDGRFA, associated with the activation of oncogenic signaling pathways, cell proliferation, angiogenesis and tumor progression, may suggest that pediatric DLBCL could be more aggressive than adult cases, even though survival is better in children17. The gene discussed is NOS3; the disease is diffuse large B-cell lymphoma.