Neutrophils with high levels of chemokine receptors are induced to migrate by chemokine ligands (such as interleukin (IL)-826 and granulocyte colony-stimulating factor (G-CSF)27) that are secreted by tumor cells,28 stromal cells, or other immune cells to form circulating neutrophils outside the bone marrow.29 They are further recruited to the TME by a “chemokine storm” to form TANs, known as chemotaxis30 (Fig. 2). This evidence concerns the gene CSF3 and neoplasm.