Melanoma cells promote neutrophil β2-integrin expression by producing and secreting IL-8.84 In turn, neutrophil β2-integrin binds to intercellular adhesion molecule 1 on melanoma cells, tethering circulating tumor cells (CTCs) to the endothelium of the target organ and promoting tumor migration across the endothelium.84 Here, CXCL8 is linked to neoplasm.