In contrast, the striatum from HD patients showed PKD presence predominantly in GFAP+ reactive astrocytes (Fig. 1A, bottom panels and graph), accompanied by a substantial reduction in neuronal PKD levels, as evidenced by quantification of the kinase immunofluorescence signal in GFAP+ and NeuN+ cells, respectively (Fig. 1A). The gene discussed is GFAP; the disease is Huntington disease.