Alternatively, TRPV1 and TRPA1 agonists indirectly modulate Piezo2 function, as calcium influx through these TRP channels has been shown to suppress Piezo2 channel activity via intracellular signaling pathways.51 Among neuropeptides enriched in nociceptor-like Piezo2+ DPA neurons, antibodies against α-CGRP, which have shown clinical efficacy in treating headaches,56 may offer potential therapeutic benefits for dental pain. The gene discussed is TRPV1; the disease is Headache.