Therefore, we decided to investigate the role of the miR-205-independent spliced transcript of MIR205HG hereinafter referred to as LEADR. By interrogating TCGA bladder cancer cohort, we observed that MIR205HG expression was decreased in high grade and high stage tumours, as well as in patients with lymphovascular invasion (Fig. 1C). The gene discussed is MIR205HG; the disease is neoplasm.