Therefore, we decided to investigate the role of the miR-205-independent spliced transcript of MIR205HG hereinafter referred to as LEADR. By interrogating TCGA bladder cancer cohort, we observed that MIR205HG expression was decreased in high grade and high stage tumours, as well as in patients with lymphovascular invasion (Fig. 1C). Here, MIR205HG is linked to urinary bladder carcinoma.