SERPINE1 and androgen insensitivity syndrome: Importantly, NETs make it easier for PS to reach platelet and EC surfaces, enhancing their procoagulant activity and promoting the release of vWF and plasminogen activator inhibitor-1 (PAI-1), which further contribute to thrombolysis resistance.107Di Meglio et al examined the thrombi of 199 AIS patients with large vessel occlusion using scanning electron microscopy and immunohistochemistry.