ATG9A and Hermansky-Pudlak syndrome 10: Genetic depletion of AP-3 has been described as the underlying genetic cause of Hermansky-Pudlak syndrome type 10 (HPS10), which is characterized by severe phenotypes such as inner ear degeneration, pigmentation dysfunctions, and neurological deficits.49 ATG9A localization was significantly altered in MEFmh/mh mouse embryonic fibroblasts compared with WT (MEFWT), with an accumulation of ATG9A in cytosolic vesicular structures in MEFmh/mh cells (Figures 4A and 4B).