ESCRT proteins are known to prevent lysosome rupture during infection.73 PI4P and OSBP also accumulate on Mycobacterium tuberculosis-containing vacuoles (MCVs), forming ER-contact sites that restore MCV integrity via ER-dependent repair.74 Our data demonstrate that loss of ARFIP2 enhances restriction of Salmonella infection, therefore impairing bacterial proliferation in HEK293A cells and Mycobacterium tuberculosis in human macrophages, revealing the broad significance of this repair mechanism across various cell types and pathogens. The gene discussed is OSBP; the disease is infection.