PNLIP and pancreatitis: This is consistent with the reduction in cardiac injury markers and improvement in cardiac function by pharmacologic inhibition of PPLE-induced fat necrosis by orlistat (Figures 3J–3O and 3B–3D), and also genetic deletion of PNLIP normalizing troponin-I elevation and carotid pulse distention, in both IL12,18 and cerulein pancreatitis (Figures 3B–3D).