CLPS and heart failure: We note that fat pad injections of PPLE, which contains group 1B phospholipase, PNLIP, PNLIPRP2, amylase, and CLPS (Figures 3E and 3F), mimic the phenotype and fat necrosis due to doxorubicin-induced heart failure, IL12,18 pancreatitis26,32 (Figures 3E and 3F), and cerulein pancreatitis shown previously.32