CD8A and neoplasm: The abundance of CAFs in ICI non-responders can also be verified from the experimental observations from melanoma, oral squamous cell carcinoma, and other solid tumor patients wherein the application of anti-PD1 did not result in any substantial reduction in tumor cells due to altered tumor cell position with respect to CD8 + T cells owing to the CAF-induce modification of the extracellular matrix in Oral Squamous cell carcinoma [102].