These findings align with our previous research, where aspirin (inhibiting the AA pathway) or P2Y12 inhibitors (inhibiting the ADP pathway) were studied for their effects on miRNA levels in healthy volunteers and patients with symptomatic carotid atherosclerosis.1 P2Y12 inhibition led to decreased miR-150 levels, while aspirin did not.1 Conversely, aspirin reduced miR-21 levels in a dose-dependent fashion, while P2Y12 inhibitors had no effect.1 The increased release of miR-150 to ADP and miR-21 to AA is intriguing, given the literature on miR-150, ADP and inflammation. The gene discussed is P2RY12; the disease is carotid atherosclerosis.