The present study aimed to determine the chemical composition of ethanolic extract from propolis produced by Plebeia catamarcensis (EEP-Pc) and Tetragonisca fiebrigi (EEP-Tf), as well as their in vitro and in vivo antioxidant effects, lifespan influence and induced paralysis in Caenorhabditis elegans, mutant model for Alzheimer’s disease. This evidence concerns the gene PC and Alzheimer disease.