LAG3 and neoplasm: Importantly, we have shown that T cells from PWH had a lower threshold to upregulate the immunoregulatory receptors LAG3, TIM3, PD-1, and CD39 and, strikingly, were less able to induce tumor killing of HLA-matched tumor cells, demonstrating that PWH, even after viral suppression, harbored both phenotypic and functional differences that could affect the response to neoantigens.