Of note, for every interaction measured (CD4+ with CD8+ T cells, TAMs with tumor, TAMs with CD4+ T cells, and TAMs with CD8+ T cells), the average distances between cells in tumors from PWH compared with those from PWOH, despite similar numbers of cells within each cell population (Supplemental Table 4), statistically significant differences in minimum distances to the tumor were observed for all 3 immune cell populations (Figure 6B), with the greatest effect size seen for CD68 cells (r = 0.51), followed by CD8 cells (r = 0.28). Here, CD68 is linked to neoplasm.