Here, we aimed to perform a bioinformatic analysis of the overall contribution of the tag SNPs of genes C11orf58 (Hero-20), C19orf53 (Hero-11), C9orf16 (Hero-9), C19orf53 (Hero-11), SERBP1 (Hero-45), and SERF2 (Hero-7), encoding the Hero-proteins to cardiovascular diseases. The gene discussed is C19orf53; the disease is cardiovascular disorder.