IGHE and neoplasm: Clustering of these receptors likely provides an advantageous way for precisely detecting repetitive epitope patterns found on parasites or tumor cells overexpressing tumor antigens allergens, but also allergens, which can trigger undesired excessive immune system activation.[41] Due to the high affinity binding, FcɛRI stably associates with monomeric IgE on the mast cell surface, enabling antigen recognition, receptor crosslinking, and the subsequent release of inflammatory mediators, including preformed granules, lipid mediators, and cytokines.