CD274 and neoplasm: Secondly, the natural compound amentoflavone has attracted much attention due to its multi‐target properties: on the one hand, it can inhibit downstream STAT3 phosphorylation by directly binding to GABRP, block IL‐10/CCL22 secretion, and reduce Tregs infiltration [71]; on the other hand, it can also synergistically enhance the efficacy of PD‐L1 inhibitors and may restore anti‐tumor immune responses by regulating T cell exhaustion markers [72].