When evaluating DEG in choroid plexus epithelial cells, genes encoding solute transporters reported to be up-regulated in the hydrocephalus model [48], forming complex together with SPAK (Stk39), including NKCC1 (Slc12a2), CLIC6 (Clic6) and KCNJ13 (Kcnj13) were more abundant in ApoE-KO; BAC/APOL1-G1 mice (Figure 2D and E). The gene discussed is KCNJ13; the disease is Hydrocephalus.