The AND gate FFL suggests that transient changes in TGF‐β can modulate miR‐155 and SOX10, but MITF is resistant to transient changes, requiring sustained TGF‐β signaling for expression changes in MITF that occur with a delay compared to SOX10 upregulation that causes phenotype switching of tumor cells, for example, from an invasive to a proliferative phenotype.48, 214. This evidence concerns the gene TGFB1 and neoplasm.