SOX10, which is essential for melanocyte development, emerges as a critical mediator of phenotypic switching, as evidenced by SOX10‐deficient melanoma cells exhibiting invasive characteristics and resistance to BRAF and MEK inhibitors while paradoxically showing enhanced sensitivity to cIAP1/2 inhibitors32, 122—a finding with potential therapeutic implications for targeting resistant melanoma. This evidence concerns the gene MAP2K7 and melanoma.