Compared with those in the T2DM group, the expression levels of Cyp51, Hsd17b7, Cyp7a1, Cyp7b1, Abcc3, Idi1, and Cyp2c22 in the M-Cili-F group were significantly greater (p < 0.05), and those of Cyp51, Hsd17b7, Fdft1, Slc27a5, Cyp7a1, Cyp7b1, Abcc3, Ugt1a6, Apoa2, Apoc1, Fabp5, Irs3, Idi1, and Cyp2c22 in the M-Cili-R group were restored compared with those in the T2DM group (p < 0.05). Here, CYP51A1 is linked to type 2 diabetes mellitus.