In conclusion, both FCJ and RCJ have hypoglycemic, lipid-lowering, and hepatoprotective effects, long-term oral administration of raw and fermented Cili juice with T2DM-associated NAFLD could ameliorate hyperglycemia and dyslipidemia, reduce abnormal lipid accumulation in the liver, decrease abnormally elevated indicators of liver function and improve insulin expression in the pancreas. This evidence concerns the gene INS and metabolic syndrome.