Compared with those in the control group, the expression levels of Cyp51, Hsd17b7, Faft1, Apoa2, and Idi1 were significantly downregulated, whereas the expression levels of Cyp7a1, Cyp7b1 and Cyp2c22 were upregulated in the T2DM group (p < 0.05). This evidence concerns the gene CYP51A1 and type 2 diabetes mellitus.