SIRPA and neoplasm: Strategies include blocking “do not eat me” signals like CD47 (recognized by SIRPα on macrophages) or CD24 (recognized by Siglec-10) to unleash macrophage phagocytosis of tumor cells, inhibiting the recruitment of pro-tumor monocytes using CSF-1R inhibitors, or attempting to repolarize pro-tumor M2-like TAMs towards an anti-tumor M1-like phenotype using various agents (Li et al., 2020).