CD47 and neoplasm: Overcoming TAM-mediated resistance involves strategies targeting their recruitment (e.g., CCL2/CCR2 blockade), survival/differentiation (e.g., CSF-1/CSF-1R inhibition), function (e.g., blocking “do not eat me” signals like CD47), or attempting to repolarize them towards an anti-tumor M1-like state (Li et al., 2023).