It has also been found that menthol arrests the cell cycle at the G0/G1 phase in androgen-independent prostate cancer cells and the G2/M phase in PC3 prostate cancer cells by downregulating CDK2, 4, and six and downregulating downstream signaling of polo-like kinase 1 (PLK1), respectively (Figure 4) (Zhang et al., 2019; Kamran et al., 2022). This evidence concerns the gene CDK2 and Familial prostate cancer.