Moreover, patients with severe depression have elevated levels of NLR and other anti-inflammatory cytokines (such as interleukin [IL]-10 and C-reactive protein) compared to healthy individuals (Demir et al., 2015; Demircan et al., 2015), and elevated NLR levels can increase the risk of suicide in depression patients (Ekinci and Ekinci, 2017). This evidence concerns the gene IL10 and major depressive disorder.