Aloe-Emodin has positive effects on PSD rats by improving depression, significantly improving behavioural functioning in PSD rats, decreasing the level of depression, increasing their activity and curiosity, ameliorating brain tissue injuries and lesions, increasing the number of neurons in the brain tissues and reducing the number of brain tissue and brain tissue AQP3, AQP4, AQP5, GFAP, TRPV4 content, and increase BDNF, NTF3 protein expression. Here, TRPV4 is linked to major depressive disorder.