The activation of the NLRP3 inflammasome may induce inflammation (Franke et al., 2021), enhance BBB permeability (Wang et al., 2020), exacerbate recurrent stroke (He et al., 2020), and the activation of hippocampal microglial NLRP3 inflammasome vesicles can facilitate chronic stress-induced depression-like behavior in rats (Feng et al., 2019). This evidence concerns the gene NLRP3 and depressive disorder.