CRP and major depressive disorder: Moreover, patients with severe depression have elevated levels of NLR and other anti-inflammatory cytokines (such as interleukin [IL]-10 and C-reactive protein) compared to healthy individuals (Demir et al., 2015; Demircan et al., 2015), and elevated NLR levels can increase the risk of suicide in depression patients (Ekinci and Ekinci, 2017).