Studies have found that in a mouse model of sepsis, the activation of inflammatory vesicles in HSC leads to increased levels of connective tissue growth factor (CTGF) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), contributing to increased collagen deposition and hepatic fibrosis in liver tissues (Akiko et al., 2022). The gene discussed is CCN2; the disease is Hepatic fibrosis.