Macrophage pyroptosis plays a crucial role as an inflammatory mechanism in sepsis-induced lung injury, Li et al. (Min et al., 2024) identified that CircMAPK1 was elevated in patients with septic lung injury, and knockdown of circMAPK1 protected against LPS/ATP-impaired cell viability and macrophage pyroptosis via WNK1/NLRP3 axis. Here, NLRP3 is linked to Sepsis.