NLRP3 and Sepsis: Bai et al. (Xue et al., 2024) reported the potential interaction of LncRNA and pyroptosis, they found that LncRNA SOX2OT mitigates sepsis-induced myocardial injury by suppressing pyroptosis through the EZH2/Nrf-2/NLRP3 signaling pathway, conversely, SOX2OT knockdown exacerbated LPS-induced levels of inflammatory factors and procalcitonin, and increased the expression of pyroptosis-related proteins and lactate dehydrogenase.