In our study, the T allele was associated with increased MTX clearance, suggesting reduced plasma concentrations in individuals with GT or TT genotypes, which may partly account for previously reported poorer 3-year disease-free survival among ABCC4 rs2274407 T allele carriers with Pre-B cell acute lymphoblastic leukemia (P = 0.00019; OR, 13.17; 95% CI, 2.55–68.11) (Mesrian Tanha et al., 2017). The gene discussed is ABCC4; the disease is acute lymphoblastic leukemia.