CCN2 and diabetes mellitus: Mouse CCN2 deletion in either cardiomyocytes or activated fibroblasts showed that CCN2 in cardiomyocytes promoted only fibrotic remodeling, whereas CCN2 from fibroblasts showed obvious fibrotic features, indicating that CCN2 derived from fibroblasts was involved in diabetes-mediated cardiac remodeling (Gravning et al., 2013).