A comparison of the studied tumor markers sensitivity of NSCLC early stages (I and II) detection revealed the following pattern: CA-62 (92%) > CEA (37%) > CYFRA 21-1 (9%) and SCC (9%) > NSE (4.5%) > CA-125 (3%) > CA-15-3 (1.5%) > CA-19-9 (1%). This evidence concerns the gene SERPINB3 and non-small cell lung carcinoma.