The best sensitivity values for early-stage detection (I and II) NSCLC were observed for CA-62 (92%) among all TMs: CEA (37%), CYFRA 21-1 (9%), SCC (9%), NSE (4.5%), CA-125 (3%), CA 15-3 (1.5%), and CA 19-9 (1%) (Figure 1). The gene discussed is ENO2; the disease is non-small cell lung carcinoma.