The results of the clinical study demonstrated that using the biomarkers combination (CA-62, CEA and CYFRA 21-1) allows increasing the Specificity of CT diagnostics for patients with pathological changes on the tomogram, improving the interpretation of visualized localized focus, and improving the accuracy of differential diagnosis at detecting early stages of LC up to 94%. Here, CEACAM5 is linked to laryngotracheoesophageal cleft.