We studied a number of various TM combinations (CEA, CYFRA 21-1 & SCC; CEA, CA-125 & CYFRA 21-1; CEA, CA -125 & CA 15-3; CEA, CA-62, CYFRA 21-1 & SCC; CEA,CA-62,CYFRA 21-1 &CA-125; CA 15-3, CA-62 &CYFRA 21-1; CEA, CA-62 and CYFRA 21-1) aiming to find the utmost effective TM panel for early-stage LC detection. This evidence concerns the gene CEACAM5 and laryngotracheoesophageal cleft.