We found that the levels of CA125, NSE, NLR, PLR, and SIRI in the oral squamous cell carcinoma group were significantly higher than those in the healthy control group (PCA125<0.001, PNSE=0.004, PNLR=0.034, PPLR=0.035, PSIRI=0.012). The gene discussed is ENO2; the disease is oral cavity squamous cell carcinoma.