To investigate the changes of serum carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) in patients with oral squamous cell carcinoma(OSCC) and their diagnostic value for OSCC. The gene discussed is ENO2; the disease is oral cavity squamous cell carcinoma.