DKC1 and familial pancreatic carcinoma: Although this study did not directly explore how DKC1 affects metabolic signaling pathways, considering the critical role of DKC1 in cell proliferation and metabolism, it is hypothesized that it may promote metabolic reprogramming of pancreatic cancer cells by regulating intracellular metabolic enzyme activities or metabolic signaling pathways (e.g., PI3K/AKT, mTOR, etc.).