We selected surgical samples from patients with metastatic and nonmetastatic NPC for immunohistochemical (IHC) and immunofluorescence (IF) staining to verify the expression of CENPN in metastatic NPC and the relationship between the CENPN/STAT3/USP37 axis and NPC metastasis. This evidence concerns the gene STAT3 and nasopharyngeal carcinoma.