MLH1 and colorectal carcinoma: Variations in these genes have been reported in large cohorts of patients with highly significant associations with the development of CRC, such as MSH2 (OR: 18.1), MLH1 (OR: 8.6), and APC (OR: 49.4), supporting the importance of germline variant identification studies in an unselected population to contribute to the generation of genetic assessment policies and variant interpretation in CRC (95).