Variations in these genes have been reported in large cohorts of patients with highly significant associations with the development of CRC, such as MSH2 (OR: 18.1), MLH1 (OR: 8.6), and APC (OR: 49.4), supporting the importance of germline variant identification studies in an unselected population to contribute to the generation of genetic assessment policies and variant interpretation in CRC (95). The gene discussed is APC; the disease is colorectal carcinoma.