Only about 5% to 10% of CRC cases are due to high or moderate penetrance genetic variants associated with hereditary cancer syndromes such as Lynch syndrome (MLH1, MSH2, MSH6, PMS2, and EPCAM), familial adenomatous polyposis (APC), and MUTYH-associated polyposis (18). This evidence concerns the gene PMS2 and colorectal carcinoma.