Of the total germline variants classified as oncodriver by BoostDM, a higher proportion of changes in genes related to CRC predisposition syndromes was identified compared to filter A. Significantly, 20.6% of molecular variants were found in these genes, and it was possible to identify them in genes related to Lynch Syndrome; MSH6 (n=5) and MLH1 (n=3). Here, MSH6 is linked to Down syndrome.