Additionally, the contribution of oncodriver variants in genes usually used in diagnostic panels, combined with extended molecular analysis of candidate genes, has a significant impact, as demonstrated by our results in which variants were identified in FANCC, KDR, and TCF7L2. FANCC is involved in DNA repair and transcription processes and has been associated with an increased risk of CRC (108–110). Here, TCF7L2 is linked to colorectal carcinoma.