In addition to genes associated with syndromes and genetic disorders conferring a high risk of CRC, other high-penetrance genes, such as AKT, ATM, BMPR1A, BRAF, BRCA1/2, CHEK2, CTLA4, KRAS, MYO3A, PI3KCA, PTEN, RAS, SMAD2, SMAD3, TCF7L2, TGFBR2, and TP53, as well as those classified as moderate- and lower-penetrance genes, should also be considered. The gene discussed is TP53; the disease is colorectal carcinoma.