NTHL1 and colorectal carcinoma: Additionally, this model allowed the identification of other variants in genes related to syndromic CRC, such as APC, BMPR1A, MSH2, MSH3, NTHL1, and PMS2. These molecular changes, along with those observed in genes related to DNA damage repair signaling pathways, demonstrate the ability of this artificial intelligence algorithm to detect oncodriver variants (76, 85, 86).