showed that in non-mucous rectal adenocarcinoma, the APT value of tumors in the Kirsten rat sarcoma (KRAS) -mutant group was higher than that in the wild type group (3.32% ± 0.69% vs. 2.23% ± 0.83%, P<0.001), and the cutoff value was 2.4% (37). The gene discussed is KRAS; the disease is rectum adenocarcinoma.