IFNG and neoplasm: Preclinical data further demonstrate that allogeneic NK cells synergize robustly with tumor vaccines through direct tumor lysis, releasing antigenic debris to amplify vaccine-primed CD8+ T cell responses,43 while concurrent depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) converts immunologically “cold” tumors into “hot” niches characterized by elevated CD8+ T cell infiltration and IFN-γ secretion.64