A large clinical study found that MACROD2 gene expression could promote VAP-1 production in adipose tissue, and its level was positively correlated with body mass index (104), and higher levels of VAP-1 were also observed in obese mice, suggesting that obesity and related genetic factors may stimulate the production of VAP-1 in adipose tissue (94). This evidence concerns the gene AOC3 and obesity due to melanocortin 4 receptor deficiency.