Cluster analysis showed that the research frontier hotspots in this field could focus on three main topics: the functional role and mechanism of irisin, pathological experimental research, and clinical disease research.<h4>Conclusion</h4>In recent years, research on irisin in the nervous system has primarily centered on elucidating its neuronal regulatory mechanisms and neuroprotective effects, along with their potential applications in neurological disorders. This evidence concerns the gene FNDC5 and nervous system disorder.