ATP7B and Wilson disease: In Wilson’s disease (WD) mutations of the P-adenotriphosphate7Bprotease (ATP7B) encoding gene on chromosome 13q14.3-q21.1 (1–5) lead to disturbed synthesis of ATP7B which is necessary for the excretion of copper (CU) from the liver into the bile (6, 7) and the incorporation of copper into apo-ceruloplasmin to produce the main copper transport protein holo-ceruloplasmin (CER) in the hepatocytes (8).