Among the laboratory indicators, lactate dehydrogenase (LDH), N-terminal pro-B-type natriuretic peptide (NT-proBNP), hydrogen ion concentration index (pH), hemoglobin (Hb), serum albumin (Alb), and C-reactive protein to albumin ratio (CRP/Alb) were the independent influencing factors for the prognosis of children with brain injury. This evidence concerns the gene CRP and brain injury.