It was found that the expression of PYGB in many cancer tissues was higher than that in normal tissues (GBM (Glioblastoma), GBMLGG (Glioblastoma and Lower Grade Glioma), LGG (Lower Grade Glioma), BRCA (Breast Cancer), LUAD (Lung Adenocarcinoma), KIRP (Kidney Papillary Cell Carcinoma), STAD (Stomach Adenocarcinoma), HNSC (Head and Neck Squamous Cell Carcinoma), KIRC (Kidney Renal Clear Cell Carcinoma), LUSC (Lung Squamous Cell Carcinoma), LIHC (Liver Hepatocellular Carcinoma), PAAD (Pancreatic Adenocarcinoma), etc., Figure 1A). The gene discussed is PYGB; the disease is breast cancer.