When evaluating antigen-specific degranulation at 4 hours post-culture, LTBI/COVID-19 exhibited a higher frequency of T CD8+CD107a+ cells compared to COVID-19 when stimulated with BCG (p<0.05), and higher than LTBI when it was stimulated with spike (p<0.05) (Figure 5B, right). The gene discussed is CD8A; the disease is COVID-19.