The results revealed that the high abundance of F. nucleatum (HR=4.990, 95% CI: 1.963-11.648, p=0.001), BRAFV600E mutation (HR=12.296, 95% CI: 3.059-49.423, p<0.001), and poor differentiation (HR=4.080, 95% CI: 1.333-12.485, p=0.014) were independent risk factors, and advanced stage (III + IV) was a protective factor (HR=0.194, 95% CI: 0.063-0.595, p=0.004) for MLH1 deficiency (Figure 1D). Here, MLH1 is linked to hyperinsulinemic hypoglycemia, familial, 4.