POFUT1 and Dowling-Degos disease 1: HS associated with other diseases like Dowling–Degos disease (DDD), implicates genes such as POFUT1 (Protein O-Fucosyltransferase 1), POGLUT1 (Protein O-Glucosyltransferase 1), and PSENEN. These genes may increase disease susceptibility by influencing Notch signaling (116, 117).