High-risk HPV E6 and E7 can also induce cervical cancer cells to secrete chemokine ligand 10 (CXCL 10), activate the JAK-STAT pathway, leading to the upregulation of PD-L1 expression, and produce immune escape by stimulating the interaction between PD-1 and PD-L1 (10). Here, CD274 is linked to cervical cancer.