Three DRB1~DQB1 haplotypes were strongly associated with T1D: DRB1⁣∗03:01:01~DQB1⁣∗02:01:01 (OR = 4.27, p=0.002), DRB1⁣∗09:01:02~DQB1⁣∗02:02:01 (OR = 4.54, p=0.005), both predisposing; and DRB1⁣∗15:03:01~DQB1⁣∗06:02:01 (OR = 0.35, p=0.009), protective. The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.