TEK and pancreatic neuroendocrine tumor: TiE2 is a receptor tyrosine kinase, and patients with PDAC with higher TiE2+ TAM frequencies have shown a greater risk of tumor development as a metastatic disease,195,196 whereas the TiE2 inhibitor rebastinib has been shown to be effective in reducing the growth and metastasis of pancreatic neuroendocrine tumors in mice.195