SIRPA and neoplasm: Depletion of SIRPα on TAMs enhances the efficacy of RT, with RT-mediated activation followed by potent pro-inflammatory features and immunogenic antigen presentation by SIRPα-deficient macrophages within tumors that confer a tumoricidal microenvironment highly infiltrated by tumor-specific cytotoxic T cells, natural killer (NK) cells, and inflammatory neutrophils.182