TAMs can induce CD4+ T cells to differentiate into T cell subsets with tumor-promoting functions, such as Th2, Th17, and Treg populations, and in PDAC, this effect can be achieved through NOD-like receptor family pyrin domain containing 3 (NLRP3) signals in the TAMs via IL-1β.137. The gene discussed is CD4; the disease is neoplasm.